Intraarticular injection of synovial stem cells promotes meniscal regeneration in a rabbit massive meniscal defect model
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چکیده
منابع مشابه
Intra-articular Injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect.
Osteoarthritis in the knees, which can be caused by meniscal defect, constitutes an increasingly common medical problem. Repair for massive meniscal defect remains a challenge owing to a lack of cell kinetics for the menisci precursors in knee joint. The synovium plays pivotal roles during the natural course of meniscal healing and contains mesenchymal stem cells (MSCs) with high chondrogenic p...
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BACKGROUND Stem cell regeneration is the holy grail of meniscal tissue repair. Currently, the best treatment is to preserve the original meniscus but if it fails, a partial meniscectomy is indicated to delay the onset of osteoarthritis. MATERIALS AND METHODS The authors present a systematic review to determine the up-to-date evidence underlying the use of mesenchymal stem cells for meniscal r...
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Transplantation of mesenchymal stem cells (MSCs) is a potential therapy for meniscus regeneration. However, when using single cell suspension injection, there is frequently a significant loss of cells, with only a small percentage of cells remaining at the target site. This issue may be solved with the use of MSC sheets. In the present study, we investigated whether the use of MSC sheets were a...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2013
ISSN: 0736-0266
DOI: 10.1002/jor.22370